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Although adolescent girls are the main population for prophylactic human papillomavirus ( HPV ) vaccines, adult women who remain at risk of cervical cancer can also be vaccinated. Data from the inte ...


It has been assessed the risk of maternal, fetal, and neonatal outcomes associated with the administration of an MF59 adjuvanted A/H1N1 vaccine during pregnancy. The trial was conducted in singleto ...


The objective of a study was to measure the effectiveness of the quadrivalent human papillomavirus ( HPV ) vaccine against cervical abnormalities four years after implementation of a nationally funded ...


Determining vaccine dose-level protection is essential to minimize program costs and increase mass vaccination program feasibility. Currently, a 3-dose vaccination schedule is recommended for both t ...


In low-income countries, live measles vaccine reduces mortality from causes other than measles infection. Such nonspecific effects of vaccines might also be important for the health of children in hig ...


In March 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine ( PCV10 ), which was licensed based on non-inferiority of immunological correlates of protection compared with the seven- ...


The TGA ( Therapeutic Goods Administration ) has been undertaking enhanced monitoring of the meningococcal B vaccine, Bexsero. Bexsero is the first vaccine in Australia intended to prevent invasive ...


Health professionals are reminded that, to minimise the risk of fever and febrile convulsion, measles, mumps, rubella, varicella vaccine should not be administered as the first dose of measles-contain ...


Present combination antiretroviral therapy ( cART ) alone does not cure HIV infection and requires lifelong drug treatment. The potential role of HIV therapeutic vaccines as part of an HIV cure is und ...


International postlicensure studies have identified an increased risk of intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq ( RV5, a pentavalent vaccine ) and Rota ...


Rates of varicella have decreased substantially in countries implementing routine varicella vaccination. Immunisation is possible with monovalent varicella vaccine or a combined measles-mumps-rubella- ...


Merck & Co has announced that in the pivotal phase III efficacy study, its investigational 9-valent HPV vaccine ( V503 ) prevented approximately 97% of cervical, vaginal and vulvar pre-cancers cau ...


Pfizer has announced that the Community-Acquired Pneumonia Immunization Trial in Adults ( CAPiTA ), the landmark study of approximately 85,000 subjects evaluating the efficacy of Prevenar 13 ( pneumoc ...


The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Gui ...


Enterovirus 71 ( EV71 ) outbreaks are a socioeconomic burden, especially in the western Pacific region. Results of phase 1 clinical trials suggest an EV71 vaccine has a clinically acceptable safety pr ...


BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A ( MVA85A ), was designed to enhance the protective ...


A vaccine for enterovirus 71 ( EV71 ) is needed to address the high burden of disease associated with infection. Researchers have assessed the efficacy, safety, immunogenicity, antibody persistence, a ...


A safe and effective vaccine for the prevention of human immunodeficiency virus type 1 ( HIV-1 ) infection is a global priority.Researchers have tested the efficacy of a DNA prime-recombinant adenovir ...


The influenza A(H1N1) 2009 monovalent vaccination programme was the largest mass vaccination initiative in recent US history. Commensurate with the size and scope of the vaccination programme, a proje ...


The candidate malaria vaccine RTS,S/AS01E has entered phase 3 trials, but data on long-term outcomes are limited.For 4 years, researchers followed children who had been randomly assigned, at 5 to 17 m ...


During the 2009 influenza A (H1N1) pandemic, pregnant women were at risk for severe influenza illness. This concern was complicated by questions about vaccine safety in pregnant women that were raised ...


A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis. Based on an animal model, the study conducted by the FDA ( Food and ...


The Committee for Medicinal Products for Human Use ( CHMP ) has finalised its assessment of an application to extend the use of Menveo to infants aged 2 to 23 months. The CHMP did not consider the res ...


Acellular pertussis vaccines effectively prevent pertussis in vaccinated individuals, but may fail to prevent colonization and transmission to uninfected individuals, according to a study. Acellular v ...


Initial vaccinations for human papillomavirus ( HPV ) at a young age is important for maximizing quadrivalent HPV vaccine effectiveness according to a Swedish study.HPV vaccination programs have been ...


Numerous studies have shown that inflammation has a relevant role in the pathogenesis of atherosclerosis as well as of acute coronary syndromes. Moreover, markers of inflammation predict cardiovascul ...


Inflammation, platelet reactivity and cardiac autonomic dysfunction increase the risk of cardiovascular events, but the relationships between these prognostic markers are poorly defined. In a stud ...


The FDA ( Food and Drug Administration ) and CDC ( Centers for Disease Control and Prevention ) routinely monitor the safety of all U.S. vaccines by using several vaccine safety surveillance systems, ...


The FDA ( Food and Drug Administration ) has approved the vaccine Gardasil for the prevention of anal cancer and associated precancerous lesions due to human papillomavirus ( HPV ) types 6, 11, 16, an ...


An experimental vaccine intended to prevent genital herpes disease in women, although generally safe and well-tolerated, proved ineffective when tested in the recently concluded clinical study known a ...


Most people experience normal, usually mild reactions that include a sore arm, fever, and body aches. In recent tests, one in three people felt bad enough to miss work, school, or recreational activit ...


The EMEA ( European Medicines Agency ) has received reports of deaths in women who had previously received Gardasil, including two reports concerning the sudden and unexpected deaths of two young wome ...


The FDA ( Food and Drug Administration ) has approved Rotarix, a vaccine for the prevention of rotavirus, an infection that causes gastroenteritis ( vomiting and diarrhea ) in infants and children. Ro ...


In the STEP study, one of two phase II trials of investigational HIV vaccine ( V520 ), the vaccine was not effective at either preventing infection in volunteers not previously infected with HIV or at ...


HPV infection is necessary for the development of cervical cancer and the vaccine may prevent primary infection with HPV types 16 and 18. However, Abby Lippman, chair of the Canadian Women's Health N ...


The National Vaccine Information Center ( NVIC ) issued a new report on HPV vaccine ( Gardasil ) safety analyzing adverse event reports to the federal Vaccine Adverse Event Reporting System ( VAERS ). ...


The FDA ( Food and Drug Administration ) has expanded the approved age range for Menactra, a bacterial meningitis vaccine, to include children ages 2 to 10 years. Meningitis is a serious inflammati ...


Researchers have reported that women who are positive for HPV DNA, do not benefit from Cervarix, a vaccine against HPV 16/18 L1 virus-like particle. HPV is the sole cause of cervical cancer, and ty ...


In a commentary published in the Canadian Medical Association Journal ( CMAJ ), Abby Lippman, an epidemiologist at McGill University in Montreal, Canada, and colleagues wrote that there is no urgent n ...


On June 8th 2006, the FDA ( Food and Drug Administration ) announced the approval of Gardasil, and on June 29th the Advisory Committee on Immunizations Practices ( ACIP ) voted to recommend adding Gar ...


A team of researchers led by Irun Cohen of the Weizmann Institute of Science Immunology Department has revealed the molecular mechanism of a vaccine for type 1 diabetes. The new findings should he ...


The FDA ( Food and Drug Administration ) has approved Gardasil, the first vaccine developed to prevent cervical cancer, precancerous genital lesions and genital warts due to human papillomavirus ( HPV ...


The FDA ( U.S. Food and Drug Administration ) has approved Gardasil, the first vaccine developed to prevent cervical cancer, precancerous genital lesions and genital warts due to human papillomavirus ...


The FDA ( U.S. Food and Drug Administration ) has approved RotaTeq, a live, oral, vaccine for use in preventing rotavirus gastroenteritis in infants. Infection with rotavirus is a leading cause ...


In a study of more than 68,000 infants published in the New England Journal of Medicine, the vaccine Rotateq demonstrated that it can safely prevent 98 percent of severe cases of viral diarrhea and vo ...


Approximately 2.5 million people received the intranasal influenza vaccine the last 2 flu seasons, and a new study did not identify unexpected serious risks associated with use of this vaccine. Unt ...


Adverse neurologic reactions from smallpox vaccination were generally mild and the rate of specific syndromes did not exceed baseline estimates. Rare adverse events causally associated with smallp ...


There was a low rate of life-threatening adverse reactions to the smallpox vaccine administered to potential first responders to a bioterrorism incident, possibly attributable to rigorous vaccine safe ...


A researcher at University of Central Florida has found an effective method of producing large quantities of anthrax vaccine. Mice immunized with a vaccine produced in UCF Henry Daniell's laborator ...


Studies of influenza vaccine effectiveness in elderly people substantially overestimate vaccine benefits, according to new research from the US published in the International Journal of Epidemiology ( ...



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